GREGoRi Innovation Projects (U01 Clinical Trial Optional)

The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research on proof of concept studies that explore novel strategies for identifying the gene(s) or variant(s) underlying rare genetic disorders, which take advantage of new and emerging molecular technologies. A primary goal of this initiative is to move beyond the current state of the art approach that uses DNA sequencing-based methods as an initial step. Examples of work that would be within scope include pilot studies using emerging technology like multi-omics, or that evaluate the effectiveness of using molecular methods like RNA-seq or methylation as an initial step. Technologies that show potential in these proof of concept studies will be integrated into the activities of the Technology Integration Center in later years. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2026. This NOFO will utilize the U01 activity code.