Engineering of Biomedical Systems

The Engineering of Biomedical Systems (EBMS)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Cellular and Biochemical Engineering; and 4) Disability and Rehabilitation Engineering. The goal of theEBMS program is to provide research opportunities for creating discovery-level and transformative projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term.EBMS projects must be at the interface of engineering and biomedical sciences. They are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. The project must include objectives that advance both engineering and biomedical sciences. EMBS projects should focus on high-impact, transformative methods and technologies -- especially those that potentially will have a broad impact on biomedical challenges. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering: Development of validated models (living or computational) of normal and pathological tissues and organ systems that can support improved fundamental understanding of these systems or development and testing of medical interventions, Design and validation of systems that integrate living and non-living components for improved understanding, diagnosis, monitoring, and treatment of disease or injury, Advanced biomanufacturing of three-dimensional tissues and organs, and Design and subsequent application of technologies and tools to investigate fundamental physiological and pathophysiological processes. Innovative proposals outside of these specific areas of biomedical engineering may be considered.However, prior to submission, it is strongly recommended that the Principal Investigator (PI) contacts the Program Director to avoid the possibility of the proposal being returned without review. Related programs also fund biomedical engineering research, and PIs are encouraged to examine these to find the appropriate program for submission. The long-term impact of the projects can be related to fundamental understanding of cell and tissue function in normal and pathological conditions, effective disease diagnosis and/or treatment, or improved health care delivery. The EBMS program does not support proposals having as their central theme drug design and delivery, the development of biomedical devices that do not include a living biological component, or thedevelopment of animal models of disease.For consideration by the EBMS program, proposals that advance the design of tools or technologies should also apply those technologies to advance knowledge in biomedical science.NSF does not support clinical trials; however, feasibility studies involving human volunteers may be supported if appropriate to the project objectives. Furthermore, although research on biomaterials, cellular biomechanics, or manufacturing systems may constitute a part of the proposed studies, such research cannot be the central theme or key focus area of the proposed work.Biomaterials-focused projects should consider the Biomaterials (BMAT) program in the Division of Materials Research (DMR), while cellular biomechanics projects should consider the Biomechanics and Mechanobiology (BMMB) program and manufacturing systems proposals should consider the Manufacturing Machines and Equipment (MME) program, both in the Division of Civil, Mechanical, and Manufacturing Innovation (CMMI). The duration of unsolicited awards is generally one to three years. The typical award size for the program is around $100,000 per year, with allowance of up to $130,000 per year for multidisciplinary collaborative projects or $200,000 per year for those involving investigators from multiple institutions. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Faculty Early Career Development(CAREER)program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URLherefor more information. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Further details are available in theProposal and Award Policies and Procedures Guide(PAPPG)download foundhere.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be foundhere. COMPLIANCE: Proposals which are not compliant with theProposal and Award Policies and Procedures Guide (PAPPG)will be returned without review.