Notice of Intent to Publish a Notice of Funding Opportunity for Alzheimer's Clinical Trials Consortium (ACTC) Clinical Trials (R01 Clinical Trial Required)

The National Institute on Aging intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to develop and implement multi-site Phase Ib to III clinical trials of promising pharmacological and non-pharmacological interventions that may prevent, delay, or treat the symptoms of Alzheimer's disease (AD) and AD-related dementias (ADRD) using the Alzheimer's disease Clinical Trials Consortium (ACTC) trial coordination and management infrastructure. This NOFO will be a reissue of RFA-AG-25-010.This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.�The NOFO is expected to be published in December 2024 with expected application due dates in March 2025, June 2025, and October 2025.This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.