Registration, Storage and Distribution of Chemicals and Drugs for Pre-Clinical Discovery Evaluation and Development

Amendment 0001 - To make a correction to the Mandatory Qualification Criteria for Facility Mandatory Qualification, see attachment. Please see attachments (Pre-Solicitation Notice and Statment of Work) for complete description. The Drug Synthesis and Chemistry Branch (DSCB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the Natio al Cancer Institute (NCI) is seeking support services to operate and maintain the National Cancer Institute’s Chemotherapeutic Agents Repository (NCI-CAR). This acquisition is responsible for providing an informational interface with NCI and external investigators that are submitting or requesting research compounds; for updating of the chemical database which includes chemical, inventory, receiving and shipping information; systematic file and record keeping of both current and archival information related to repository activities; and reacquisition of samples for continued chemical and biological studies. Towards this goal, the Program acquires and evaluates about 5,000 single agents each year in anticancer assays. In addition, research samples are provided to the general research community both in vialed and plated format. NCI-CAR is responsible for receiving, storage and distribution services along with curating an inventory of approximately 500,000 - 600,000 individual samples and associated chemical, inventory and distribution data. Approximately 400 samples are received monthly, registered, and shipped to NCI testing facilities; an additional 2,500 samples are weighed inventory and shipped to research investigators both in the U.S. (including NCI) and foreign countries.