Active Motif- FactorPath Analysis

The Active Motif FactorPath ChIP-Seq Service is needed because defects in normal development during gestation can lead to disease states later in life. Specific cell signaling pathways to fully explore and understand how and why these types of diseases can occur. One method widely employed by the scientific community, ChIP-seq, is used to discern which genes make up these pathways and how they interact. ChIP-seq can identify areas of chromosomes which are bound by specific proteins and, thus, show different genes working together to produce an affect. By helping to map these pathways and build on the current knowledge of development of reproductive organs, this process will help to increase the chance that diseases will be identified early on and treatments can be found. The Reproductive Developmental Biology Group at the NIEHS is currently using this method in the lab, therefore in order to have continuous results, this same method must be employed so that the results are not altered. The applicable North American industry Classification System (NAICS) Code for this procurement is 621511 “Medical Laboratories.” Its associated Business Size Standard is $35000000.00. Line item 1. 25006--FactorPath ChIP-Seq, (No Seq, No Data Analysis). (Qty.9 each) Line item 2. 25095- Hi-C Service, Library only- (Qty. 2 each) Line item 3. 25015- HistonePath ChIP-Seq (No Seq, No Analysis)-(Qty 2 each) Line item 4. 25066- Input-Seq (No Seq, No Analysis)-(Qty 2 each) Line item 5. 25082- Tissue/Primary Cells Add-on)-(Qty 9 each) Period of performance: September 30, 2021-September 29, 2022 NIEHS will solicit and negotiate directly with Active Motif, and no solicitation will be issued. This notice of intent is not a request for competitive proposals or quotations; however, all responsible sources may submit a capability statement which shall be considered by the agency. Offerors must have an active registration in the System for Award Management (SAM.GOV) www.sam.gov. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Interested parties must express their interest and must be submitted in writing via email to Valarie K. Sims at [email protected] and are due by 10:00 AM, August 16, 2021. No faxed documents will be accepted. If no responsive statements are received by the due date, an award will be made to Active Motif.