Radiochemistry and Instrumentation Research

The Office of Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE) advances world-class biological and environmental research programs and scientific facilities for DOE missions in energy, environment, and basic research. BER hereby announce its interest in receiving applications for pilot research project grants in two topic areas, Radiochemistry and Radionuclide Imaging Instrumentation. In the area of Radiochemistry, BER invites applications for fundamental research involving particularly improvements in the synthetic methodology for incorporating the radioisotope in a wide range of organic molecules with techniques designed to allow dual or multiple labeling of the targeting molecule for dual energy or hybrid imaging techniques in vivo. In the area of Radionuclide Imaging Instrumentation, BER invites applications dealing with the design and development of new or improved radionuclide imaging instrumentation that can significantly increase the accuracy of quantitative assessments of the three dimensional spatial and temporal distribution of radiotracers in living systems with the aid of hybrid imaging techniques. Applications should focus on basic research that will significantly advance the current state of the science underpinning nuclear medicine research and applications. Responses to this Funding Opportunity Announcement (FOA) should address the development and use of highly innovative radiotracer chemistry or instrumentation technologies for quantitative in vivo measurement of site-specific (in situ) chemical reactions, their spatial distributions and metabolic perturbations, and ensuing biological processes with a high degree of accuracy.