Description
Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHBLI), National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Institute of Environmental Health Sciences (NIEHS), in conjunction with the Ataxia-Telangiectasia Children s Project (A-TCP) and the A-T Ease Foundation, invite research grant applications aimed at understanding or treating Ataxia-Telangiectasia (A-T). The aim of this FOA is to encourage basic, translational and clinical studies to determine how the symptoms of A-T develop, to stimulate the development of resources to further A-T research, to accelerate research into promising therapeutic approaches for A-T and to stimulate progress in A-T research through encouraging and facilitating interdisciplinary interactions. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental (R21) award mechanism and runs in parallel with two other FOAs of identical scientific scope (R01, PA-07-272 and R03, PA-07-274) that solicit applications under the NIH Traditional Research Project Grant (R01) mechanism, and the NIH Small Research Grant (R03) mechanism, respectively. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The R21 is not renewable. Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.