Early Identification and Treatment of Mental Disorders in Children and Adolescents (R01)

Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH), National Institutes of Health (NIH), invites investigator-initiated research grant applications for studies focused on the early identification and treatment of mental disorders in children and adolescents. Specific examples include studies focused on: the validation of early diagnosis of mental disorders in youth, especially in young children; the development of new interventions to treat mental disorders and prevent the exacerbation of associated functional impairment; the efficacy and safety of new and existing treatments; the identification and evaluation of predictors of treatment response and underlying mechanisms of action for new and existing treatments; the long-term effectiveness and impact of early intervention on later course; and the factors that promote or impede access to services and impact the effectiveness of services for these patients in community and practice settings. Assessment methods may include behavioral, neuropsychological, neuroimaging, and other physiological measures or markers. Intervention strategies to be studied may include pharmacological, psychosocial, and rehabilitative interventions, separately or in combination. Mechanism of Support. This FOA will use the NIH Research Project Grant (R01) award mechanism. Applications of related or identical scientific scope are also solicited under the NIH Small Research Grant (R03), the NIH Exploratory/Developmental Grant (R21), and the NIMH Clinical Exploratory Research Grant (R34), responding to FOAs PA-06-180, PA-06-181, and PAR-06-248, respectively. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.