Mechanisms of Alcohol and Drug-InducedPancreatitis (R01)

-Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), solicits grant applications from institutions/organizations that propose to investigate the underlying molecular, biochemical, and cellular mechanisms by which long-term alcohol ingestion and drugs lead to the development of pancreatitis. Research is also encouraged to understand the role of various predisposing factors, including substance abuse, that make the pancreas susceptible to alcoholic injury. Understanding the mechanisms as well as the role of predisposing factors may help in developing strategies for the prevention or treatment of the disease. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.