AN41--VA Western New York Healthcare System in Buffalo NY is in need of: Antimicrobial Differential, High Throughput Activity Screen

INTENT TO SOLE SOURCE: The VA Western New York Healthcare System, located at 3495 Bailey Ave. Buffalo, New York 14215 intends to sole source to, Albany Molecular Research Inc. (AMRI), at 26 Corporate Circle, PO Box 15098, Albany, NY 12212 for an antimicrobial differential, high throughput activity screen. Description of Need: An antimicrobial screening assay developed by the VA Western New York Healthcare System (Buffalo) laboratory will be performance tested and miniaturized by AMRI. Once the assay is successfully transferred to a smaller platform, a high throughput screen for PBP7/8 inhibitors will be performed using about 105,000 compounds of AMRI s ASCC 2012 compound library. This is a unique library that contains a large number of compounds. Confirmation testing will be done on up to 1,000 identified apparent active compounds. The most active compounds identified will undergo additional testing and characterization in out laboratory. The proposed work will be carried out in three tasks: Task 1: Antimicrobial Assay Transfer and Performance Testing. Task 2: High Throughput Screen for PBP 7/8 inhibitors. Task 3: Confirmation testing of up to 1,000 Apparent Active Compounds. This notice of intent to sole source is not a request for competitive quotes; however, any responsible source who believes it is capable of meeting this requirement may submit a capability statement to the contracting officer later than Monday, May 18, 2020 at 11:00 AM ET. Interest/Capability statements may be sent to Linda Buccigrossi at [email protected]. No telephone responses will be accepted. A determination not to compete the proposed requirement based upon the responses to this notice is solely within the discretion of the Government.