TECHNOLOGY TRANSFER OPPORTUNITY: Non-invasive Intracranial Pressure Measurement: LAR-18581-1

Synopsis: NASA Langley Research Center in Hampton, VA solicits inquiries from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. NASA provides no funding in conjunction with these potential licenses. THE TECHNOLOGY: Scientists at NASA Langley Research Center have developed a new analytical capability for assessment of intracranial dynamics. It offers the possibility for the monitoring of transcranial expansion and related physiological phenomena in humans resulting from variations in intracranial pressure (ICP) caused by injuries to the head and/or brain pathologies. The technology uses constant frequency pulse phase-locked loop (CFPPLL) technology to measure skull expansion caused by pressure and its variations in time. This approach yields a more accurate, more robust measurement capability with improved bandwidth that allows new analytical approaches for assessing the physiology of skull expansion under pulsatile cerebral blood flow. The dynamical quantities assessable with the CFPPLL include skull volume expansion and total fluid. Such an instrument can serve to measure intracranial dynamics with equation based algorithms, and offers a path to measure or determine quasistatic intracranial pressure, along with the pulsatile related intracranial pressure increments. Supportive measurements, such as time dependence of arterial pressure waveforms together with time dependent phase change of transcranial expansions can serve as the basis of noninvasive techniques to measure intracranial pressure. NASA is seeking to license this technology commercially in the United States. US Patent pending. To express interest in this opportunity, please respond to [email protected] with the title of this Technology Transfer Opportunity as listed in this FBO notice and your preferred contact information. Please also provide how you foresee using the technology along with a brief background of your company. Additionally, please identify any non-US interests/subsidiaries in your company as well. For more information about licensing other NASA Langley-developed technologies, please visit the NASA Langley's Technology Gateway at https://technologygateway.nasa.gov/ These responses are provided to members of NASA Langley's Office of Strategic Analysis and Business Development "OSACB" for the purpose of promoting public awareness of NASA-developed technology products, and conducting preliminary market research to determine public interest in and potential for future licensing opportunities. If direct licensing interest results from this posting, OSACB will follow the required formal licensing process of posting in the Federal Register. No follow-on procurement is expected to result from responses to this Notice.