Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should address one or more of the following: i) what modifiable exposures are driving the increase in the incidence of non-hereditary EOCs, and how do these factors vary by patient demographics? (ii) what biological mechanisms and host responses underly the increase in EOCs? and (iii) how can those at increased risk for developing EOCs be identified more effectively? This NOFO consolidates exploratory/developmental and research project funding mechanisms to streamline the application process and sustain momentum in this critical research area. Applicants have the option of submitting either an exploratory/developmental research project with a project period of up to 2 years or a research project with a project period of 4 to 5 years.